Mass Spectrometer - Delivery Mass Spectrometer. Nano-Liquid Chromatography System Coupled With A High-Resolution Mass Spectrometer According To The List Of Services. Area Of Application: Proteomanalytics (Bottom-Up) With A Focus On Relative And Absolute Quantification Of The Peptides/Proteins Including Post-Translational Modifications With High Sample Throughput. Liquid Chromatography System: - Binary Pump For River Rates Of 100 Nl/Min - 10 Μl/Min, Pressure -Stable Up To At Least 1250 Bar - High -Pressure Finger -Tight Connections - Loading Pump For Analytical Enrichment On A Trapping Column For River Rates Of At Least 1-50 Μl/Min - Column Stove For Absorption Valves For Capiling, Stable Temperature. Max. 60 ° C-Autobler With Interchangeable Sample Loop (Finger-Tight Compounds) And A Temperature Or Cool Sample Reservoir For Accommodation Of At Least 100 Hplc Vials-Max. Base Area Of 50 X 65 Cm Ion Sources:-Nanoesi-Ion Source For River Rates Between Approx. 50-2000 Nl/Min-Esi Esi Source Of At Least 1-10 Μl/Min Mass Spectrometer: - Ion Look With Electrodynamic Ion Funnel - The Mass Analyzers Must All Be Able To Work One After The Other Or In Parallel With The Others And Have The Following Characteristics: 1) Quadrupol For High Sensitivity, Stability And Ion Transaction Efficiency With Suitability For Variable Isolation: Ultra-High-Resolution Mass Analyzer With At Least R = 400 000 (Fwhm At M/Z 200), Especially For Precursor Full Scan For Precise And Clear Quantification Of The Precursor-Ion Intensity 3) High-Resolution Mass Analyzer For Ultrahohe Scan Rates Of> 167 Hz For Ms2 Spectra For More Than 10,000 Ms/Ms Spectra Per Minute- Due To Structural Restrictions, The Ms May Not Require Liquid Gas To Cool- As An Esi, Collision, Carrier And/Or Cooling Gas, Only Nitrogen Is Used- Increased Selectivity By Online Gas Phase Fractionation By Means Of Ion Mobility Separation (Optionally Identify)- Hcd (Preferred) Or Cid Fragmentation- Possibility Of Data-Dependent (Dda) And Independent Ms/Ms Scan Modes (Dia) As Well As Prm/Mrm-Like Targeted Scan Modi-Suitability For Multiplex Methods For Reporter-Ion Quantification (Itraq, Tmt, Etc.) After Isobarbar Labeling Of Peptides-High Mass Accuracy (Accuracy), Supported By An Internal Automated Mass Calibration Should Remain Stable Over A Longer Period Of Time, Deviations <1 Ppm For Internal And <3 Ppm With External Calibration Are Expected - Oil -Free Advancing Pump For Reduced Energy Consumption And Maintenance - Due To Limiting The Load, The Mass Spectrometer, Including Preliminary Vacuum Pumps, Should Weigh Less Than 800 Kg (Weight Without Lc Modules And Computer/Screen) Computer Hardware And Software: Ms Windows 11-Based Computer Including Control Software
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