Tenders Are Invited For Analysis Services – Services In The Field Of Biology And Pathophysiology Of Neuromuscular Diseases

Analysis Services – Services In The Field Of Biology And Pathophysiology Of Neuromuscular Diseases. Lmna-Related Dilated Cardiomyopathy (Lmna-Dcm) Is A Serious, Inherited Disease Caused By Mutations In The Lmna Gene. This Gene Provides Instructions For Making Proteins Called A-Type Lamins (Lamins A/C), Which Help Maintain The Structure Of The Cell Nucleus And Play An Important Role In Regulating Chromatin Organization, Gene Expression And Of The Organization Of The Cytoskeleton By Interacting With Many Other Proteins. Currently, There Is No Effective Treatment For Lmna-Dcm Because We Do Not Fully Understand The Underlying Mechanisms Of The Disease. Aim 2 Investigates The Underlying Disease Mechanism(S) That Contribute To Lmna-Related Dcm, Uncovering The Complex Cellular And Molecular Processes That Underlie The Pathogenesis And Progression Of Disease Using Cutting-Edge Technologies. The Services To Be Carried Out Are As Follows: - Quantitative Evaluation Of The Overall Architecture Of The Mt Network, The Distribution Of Post-Translational Modifications Of Tubulin And The Dynamics Of Mt In Lmna Mutant Ipsc-Cms And Healthy Controls, As Well As In Cardiomyocytes Of Adult Mice. - Tests To Determine Whether Targeting Post-Translational Modifications Of Disrupted Mts Improves Cytoskeletal And Nuclear Structure And Function. Elucidating How The Mt Cytoskeleton Is Altered In Lmna-Dcm And How These Changes Contribute To Disease Pathogenesis May Provide New Ways To Preserve Cardiac Structure And Function In Lmna-Dcm, As Well As Other Areas. Cardiomyopathies In Which The Organization Of Mt Is Disrupted. - Submission Of A Quarterly Report.