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// Set Of Reagents For Quantitative Determination Of Eosinophilic Cationic Protein By Enzyme Immunoassay No. 96 The Set Is Intended For Quantitative Determination Of Eosinophilic Neurotoxin (Edn) In Human Serum And Plasma Samples (Stabilizers Edta, Heparin, Citrate, With The Addition Of Aprotinin) By Enzyme Immunoassay. Test Applications: Human Eosinophilic Neurotoxin (Edn) And Eosinophilic Cationic Protein (Ecp) Are Members Of The Unique Ribonuclease A Subfamily. The Genes Of These Proteins Are 85% Identical, And The Structure And Catalytic Sites Are Similar To Other Members Of This Family. Eosinophil Cationic Protein (Ecp, Alternative Name Rnase 3), Neurotoxin Of Eosinophilic Origin (Eosinophilic Neurotoxin, Edn) And Main Protein (Mbp) Are The Main Mediator Proteins Of Activated Eosinophils. Ecp And Edn Are Found In The Matrix Of Large Specific Eosinophilic Granules, While Mbp Is Found In The Center Of The Granules. Ecp And Mbp Have High Cytotoxicity. All These Three Proteins Show Strong Cationic Properties, With A Ph Of 10.8-10.9. Ecp Has The Properties Of Cytotoxin, Helminthotoxin And Bacterial Toxin. The Exact Mechanism Of The Antibacterial Activity Of Esp Is Unknown, But It Is Assumed That Its Cationic Sections Destroy The Phospholipid Bilayer Of The Membrane, Similar To The Bee Venom Protein Mellitin With The Formation Of Pores. Activated Eosinophils Play An Important Role In Late Asthmatic Response And Asthmatic Inflammation Of The Respiratory Tract. Ecp Is Secreted By Activated Eosinophils And Can Serve As A Marker Of Eosinophil Activation And Degranulation.