Expression of Interest For Vitro Intrinsic Hepatic Clearance And Plasma Protein Binding Studies For Protocol Optimisation

Expression Of Interest For Vitro Intrinsic Hepatic Clearance And Plasma Protein Binding Studies For Protocol Optimisation. Description: The Present Study Aims To Implement Two In Vitro Adme Methods For The Determination Of Intrinsic Hepatic Clearance And Plasma Protein Binding (Ppb), And To Generate High-Quality Experimental Data For A Defined Set Of Selected Chemicals In Accordance With The Jrc-Provided Standard Operating Procedures (Sops). The Primary Objective Is To Produce Robust And Reliable In Vitro Adme Data Using These Two Assays Under Controlled And Harmonised Laboratory Conditions. The Jrc-Provided Sops Serve As The Methodological Foundation Of The Study, And All Critical Procedural Components Necessary For Assay Integrity And Data Quality Must Be Adhered To. A Secondary Objective Is To Perform A Critical Assessment Of The Laboratory-Specific Implementation Of The Sops Within The TendererS Facilities. Start Date For Expression Of Interest: 16/07/2026 Europe/Brussels Deadline For Expression Of Interest: 04/08/2026 03:29 Europe/Rome Tender Link : Https://Ec.Europa.Eu/Info/Funding-Tenders/Opportunities/Portal/Screen/Opportunities/Tender-Details/2B02bf9b-79C9-47Dc-A632-B21f5ad6d955-Exa