Tenders Are Invited For Laboratory, Optical And Precision Equipment (Excl. Glasses) – Maldi-Tof/Tof Mass Spectrometer For Intact Proteins And Proteoforms

Laboratory, Optical And Precision Equipment (Excl. Glasses) – Maldi-Tof/Tof Mass Spectrometer For Intact Proteins And Proteoforms. The University Hospital Of Rwth Aachen Is Purchasing A Maldi-Tof/Tof Mass Spectrometer. This Device Is Operated At The Institute For Molecular Cardiovascular Research (Imcar) And Is Required As Part Of The Dfg-Funded Collaborative Research Center Trr219 Mechanisms Of Cardiovascular Complications In Chronic Renal Insufficiency. . General Description Maldi-Tof/Tof Mass Spectrometer: What Is Required Is A Compact, Benchtop-Based Maldi-Tof/Tof Mass Spectrometer For Experimental Use In Biomedical And Translational Research According To The Current State Of The Art. The System Is Designed For Routine And High-Throughput Operation In A Multi-User Environment And Can Be Installed In Existing Laboratory Rooms Without Any Structural Adjustments. The Mass Spectrometer Must Have A Dedicated Maldi Ion Source And Be Suitable For The Analysis Of Intact Proteins And Protein Complexes Without Enzymatic Digestion (Top-Down / Native Mass Spectrometry). The Analytical Focus Is On High Molecular Weight Biomolecules From Complex Biological Samples. A Broad Mass Range Up To The High Molecular Range (? 300,000 M/Z) Is Required, Which Enables The Reliable Detection Of Large, Intact Biomolecules. Operation In Linear And Reflectron Modes Must Be Supported. For Structural Characterization, Tof/Tof-Capable Ms/Ms Functionality Is Required That Is Suitable For Automated Measurement Sequences In High-Throughput Operation. The Maldi Laser Must Be Designed For Continuous Operation And Ensure Reproducible Measurement Performance. The System Is Intended To Support Automated Sample Operation With Multi-Spot Targets. Device Control And Data Acquisition Are Carried Out Via An Integrated Software Solution That Enables Automated Measurement Processes As Well As Further Processing And Export Of The Generated Mass Spectrometry Data.