Grants Notice For Engineering Improved Stem Cell-Derived Islet Cells For Replacement Therapies (R01 - Clinical Trial Not Allowed) This Funding Opportunity Is Designed To Support Research In Understanding How To Engineer Intrinsic Characteristics Of Stem Cell-Derived Islet Cell Products That Can Result In Improved Cell Replacement Therapy Outcomes. Unlike Cadaveric Human Islets, Stem Cell-Derived Islet Cell Products Are Generated From Well-Defined And Highly Controlled Cell Bank Sources. Their Banking, Manufacturing, And Quality Control Processes Can Be Used To Instill Optimized Cell Characteristics Resulting In More Resilient And Durable Graft Viability And Function. This Funding Opportunity Aims To Stimulate Studies On Targets And Pathways Amenable To Such Engineering Approaches And To Encourage Preclinical Testing And Validation Of Such Strategies.This Nofo Is Associated With The Special Diabetes Program (Https://Www.Niddk.Nih.Gov/About-Niddk/Research-Areas/Diabetes/Type-1-Diabetes-Special-Statutory-Funding-Program/About-Special-Diabetes-Program) Which Funds Research On The Prevention, Treatment, And Cure Of Type 1 Diabetes And Its Complications, Including Unique, Innovative, And Collaborative Research Consortia And Clinical Trials Networks
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