Plasma Tau As A Biomarker And Risk Factor For Pathogenic Brain Changes In Non Demented Adults

Tender Detail

39906877
75N95021Q00155
Self Funded
Plasma Tau As A Biomarker And Risk Factor For Pathogenic Brain Changes In Non Demented Adults
ICB
Northern America
Asia-Pacific Economic Cooperation, APEC,G20
12-05-2021

Work Detail

This Is A Small Business Sources Sought Notice This Is Not A Solicitation For Proposals Proposal Abstracts Or Quotations The Purpose Of This Notice Is To Obtain Information Regarding 1 The Availability And Capability Of Qualified Small Business Sources 2 Whether They Are Small Businesses Hubzone Small Businesses Service Disabled Veteran Owned Small Businesses 8 A Small Businesses Veteran Owned Small Businesses Woman Owned Small Businesses Or Small Disadvantaged Businesses And 3 Their Size Classification Relative To The North American Industry Classification System Naics Code For The Proposed Acquisition Your Responses To The Information Requested Will Assist The Government In Determining The Appropriate Acquisition Method Including Whether A Set Aside Is Possible An Organization That Is Not Considered A Small Business Under The Applicable Naics Code Should Not Submit A Response To This Notice This Notice Is Issued To Help Determine The Availability Of Qualified Companies Technically Capable Of Meeting The Government Requirement And To Determine The Method Of Acquisition It Is Not To Be Construed As A Commitment By The Government To Issue A Solicitation Or Ultimately Award A Contract Responses Will Not Be Considered As Proposals Or Quotes No Award Will Be Made As A Result Of This Notice The Government Will Not Be Responsible For Any Costs Incurred By The Respondents To This Notice This Notice Is Strictly For Research And Information Purposes Only Background Given The Putative Role Of Tau Phosphorylation Destabilization And Aggregation In Alzheimer S Disease Pathogenesis Understanding The Biological Processes That Promote Pathological Tau Formation Is Essential The Association Between Amyloid Beta A And Early P Tau Accumulation Has Been Established Supporting The Theory That Amyloidosis Can Lead To Hyperphosphorylation Of Pathogenic Tau Isoforms In Addition Evidence That Peripheral Inflammatory Immune And Hemostatic Vascular Processes May Act As Molecular Drivers Of Tau Pathology Has Recently Emerged Using Available Data From The Baltimore Longitudinal Study Of Aging Blsa We Have The Unique Opportunity To Apply A Proteome Wide Discovery Approach To Identify Peripherally Acting Molecular Drivers Of Tau Progression In Doing So We Will Learn About The Systemic Biological Processes That May Influence Tau Progression Results Will Point To New Therapeutic Avenues For Slowing Pathogenic Tau In Those At Risk For Alzheimer S Disease To Further Understand The Peripheral Processes That May Accelerate Pathological Tau Formation Within The Brain We Will Use Stored Plasma From 700 Participants To Conduct A Comprehensive Proteomic Measurement Using Olink Technology And Examine Whether Baseline Expression Of Circulating Plasma Proteins And Identified Protein Networks Predict Longitudinal Increases In Plasma P Tau181 And Pet Defined Tau Neurofibrillary Tangles Nfts Purpose And Objectives The Purpose Of This Requirement Is To Utilize A Discovery Based Proteomics Platform In Archived Plasma Samples Collected In The Baltimore Longitudinal Study Of Aging Blsa To Identify Molecular Pathways That Accelerate Pathological Phosphorylation Of Tau In Individuals At Risk For Ad Project Requirements The Contractor Shall Perform Discovery Based Proteomic Assays On 700 Human Plasma Samples From The Blsa Cohort And Generate Proteome Wide Measurement Information For Each Participant Nia Instigators Will Use Protein Measurements To Identify Molecular Pathways That Accelerate Pathological Phosphorylation Of Tau In Individuals At Risk For Ad Anticipated Period Of Performance 3 Months Other Important Considerations The Contractor Must Perform Analysis Compatible With Previously Acquired Olink Analytes Capability Statement Information Sought Respondents Must Provide As Part Of Their Responses

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