Procurement Of Two Monolith Or Equivalent Instruments For Measuring The Binding Affinities Of A Variety Of Proteins By Microscale Thermophoresis

The U S Department Of Health And Human Services Dhhs National Institutes Of Health Nih National Cancer Institute Nci Center For Cancer Research Ccr Laboratory Of Cell Biology Lcb Requires The Procurement Of Two Instruments One With Label Free Detection By Thermophoresis And One With Labeled Detection By Thermophoresis For Measuring The Binding Affinities Of A Variety Of Proteins This Is A Combined Synopsis Solicitation For Commercial Items Prepared In Accordance With The Format In Far 12 6 As Supplemented With Additional Information Included In This Notice And Shall Be Processed In Accordance With Far Subpart 13 5 Simplified Acquisition Procedures For Certain Commercial Items This Announcement Constitutes The Only Solicitation And A Separate Written Solicitation Will Not Be Issued This Solicitation 75N91020q00025 Is Issued As A Request For Quote Rfq And Includes All Applicable Provisions And Clauses In Effect Through Far Federal Acquisition Circular Fac 2020 05 03 30 2020 Simplified Acquisition Procedures For Commercial Items The North American Industry Classification System Code Is 334516 And The Business Size Standard Is 1 000 Employees This Is A Total Small Business Set Aside 1 0 Brand Name Or Equal This Requirement Is For The Procurement Of The Brand Name Or Equivalent Instruments Described In Section 4 0 The Federal Acquisition Regulation Far Provision Far 52 211 6 Brand Name Or Equal Aug 1999 Is Applicable To This Requirement 2 0 Background The U S Department Of Health And Human Services Dhhs National Institutes Of Health Nih National Cancer Institute Nci Center For Cancer Research Ccr Laboratory Of Cell Biology Lcb Requires The Procurement Of Two Instruments One With Label Free Detection By Thermophoresis And One With Labeled Detection By Thermophoresis For Measuring The Binding Affinities Of A Variety Of Proteins Several Lcb Researchers Study Binding Affinity To Learn About Structural Biology Structure Function Relationships And The Intermolecular Interactions That Drive Biological Processes The Affinity Values Can Guide Decisions About The Biological Relevance Of A Particular Molecule Such As Whether The Molecule Under Investigation Warrants Further Screening Or Characterization Not All Detection Methods Currently Available To Lcb Allow For Accurate Affinity Measurements Of Critical Protein Pathways And Targets Protein Small Molecule Interactions Are Important For Discovery Of Novel Therapeutic Drugs Additionally Better Understanding Protein Protein Interactions Helps Better Explain The Underlining Protein Pathways It Is Because Of This Void In Lcb S Existing Technologies That Nci Is Seeking Additional Instruments To Facilitate Both Labeled And Label Free Determination Of Binding Affinities Some Situations Require Labels Fluorescent Probes That Attach To A Target So That Lcb Can Identify These Targets Of Interest The Need For A Labeled Method Is Driven By The Need For Flexibility To Measure Protein Protein Interactions And Other Interactions In More Realistic Matrices Cell Lysate Serum Plasma Or Other Complex Bioliquids Other Cases Require Label Free Detection Where Lcb Can Detect The Tryptophan Intrinsic To A Target As Non Intrinsic Labels Themselves Can Perturb A Measurement Lcb S Label Free Need Is Driven By Protein Small Molecule Interactions Looking For Targeted Therapies And Their Respective Affinities To Their Targets 3 0 Type Of Order This Is A Firm Fixed Price Purchase Order 4 0 Product Features Salient Characteristics The Following Product Features Characteristics Are Required Both Instruments Shall Measure Binding Affinities By Measuring Microscale Thermophoresis Mst This Method Is Based On The Measurement Of The Movement Of Molecules In Microscopic Temperature Gradient This Mode Of Measurement Is Complementary To Existing Technologies In The Lab Each Instrument Shall Include Control Software Instrument Control Computers And Data Analysis Software One 1 Nt Labelfree Label Free Instrument The Label Free Instrument Shall Use An Infrared Radiation Ir Laser To Generate Thermophoresis And Detect The Protein Where An Intrinsic Probe Tryptophan Is Excitable Using Ultraviolet Uv The Instrument Shall Measure Protein Small Molecule Interactions Lcb Requires Thermophoresis To Determined Bound And Unbound States Of Notoriously Unstable Biomolecules Measuring Difficult Biomolecule Targets In A Label Free Format Is Incredibly Important For Certain Protein Small Molecule Interactions Where Labels Are Not Possible Or Affect Small Molecule Binding The Instrument Shall Measure Binding Affinities Kd From 10 Nanomolar To 500 Millimolar The Instrument Shall Require A Minimum Of 4Microliters l Per Data Point Purified Proteins Can Be Difficult To Obtain So The Quantity Used In Experiments Can Be Limiting Therefore Lcb Requires Measurements On Small Sample Quantities The Instrument Shall Be Immobilization Free The Ability To Measure Binding Without Immobilization To A Surface Provides An Environment Closer To The Native Environment For The Interaction Immobilization Risks Problems By Sterically Interfering With The Interaction Limits The Experimental Range To Molecules That Allow Immobilization Measurements Shall Be Able To Be Completed In 30 Minutes Or Less To Increase Throughput Of Measurements As Assays Will Be Performed For Screening Small Molecule Inhibitors It Is Not Feasible For Measurements To Require Hours Of Run Time For The Large Number Of Measurements To Be Made The Instrument Shall Be Able To Measure Binding Affinities For Molecules With Molecular Weight Range Of 101 107 Daltons And Size Range Of 0 1 Nanometer 1 Micrometer These Are The Ranges Of Molecules That Need To Be Analyzed In The Laboratory The Instrument Shall Be Capable Of Temperature Control In The Range 22 45 0 3 C The Ability To Precisely Control The Temperature Is Critical Particularly For Comparing Across Multiple Protein Mutation States Or Small Molecule Interactions As Binding Reactions Are Sensitive To Conditions The Instrument Shall Be Able To Analyze Up To 16 Samples Per Run Medium Throughput Analysis Capabilities Are Required For Protein Drug Screening Experiments That Will Be Regularly Performed The Label Free Instrument Shall Not Exceed 13 Inches Wide X 18 Inches High X 20 Inches Deep These Dimensions Are Required To Fit In The Available Laboratory Space One 1 Nt 115 Blue Red Labeled Instrument The Labeled Instrument Shall Use An Infrared Ir Laser To Generate Thermophoresis And Detect The Protein Where A Non Intrinsic Probe Is Excitable Using Visible Wavelength Excite 488Nm Blue And 647Nm Red Lcb Requires This To Measure Protein Protein Interactions Which Would Not Be Possible Using The Label Free Uv Detection Of Tryptophan The Instrument Shall Measure Binding Affinities Kd From 1 Nanomolar To 500 Millimolar The Instrument Shall Require 1 10 Nanomolar Of The Labeled Interactor And A Dilution Series Of The Unlabeled Binding Partner Starting At 20 Fold Higher Than The Expected Kd The Instrument Shall Require A Minimum Of 4Microliters Of Labeled Interactor Per Data Point Purified Proteins Can Be Difficult To Obtain So The Quantity Used In Experiments Can Be Limiting Therefore There Is A Need For Measurements On Small Sample Quantities The Instrument Shall Be Immobilization Free The Ability To Measure Binding Without Immobilization To A Surface Provides An Environment Closer To The Native Environment For The Interaction Immobilization Risks Problems By Sterically Interfering With The Interaction Limits The Experimental Range To Molecules That Allow Immobilization Measurements Shall Be Able To Be Completed In 30 Minutes Or Less To Increase Throughput Of Measurements As Assays Will Be Performed For Screening Small Molecule Inhibitors It Is Not Feasible For Measurements To Require Hours Of Run Time For The Large Number Of Measurements To Be Made The Instrument Shall Be Able To Measure Binding Affinities For Molecules With Molecular Weight Range Of 101 107 Daltons And Size Range Of 0 1 Nanometer 1 Micrometer These Are The Ranges Of Molecules That Need To Be Analyzed In The Laboratory The Instrument Shall Be Capable Of Temperature Control In The Range 22 45 0 3 C The Ability To Precisely Control The Temperature Is Critical Particularly For Comparing Across Multiple Protein Mutation States Or Small Molecule Interactions As Binding Reactions Are Sensitive To Conditions The Instrument Shall Be Able To Analyze Up To 16 Samples Per Run Medium Throughput Analysis Capabilities Are Required For Protein Drug Screening Experiments That Will Be Regularly Performed The Instrument Shall Not Exceed 13 Inches Wide X 18 Inches High X 20 Inches Deep These Dimensions Are Required To Fit In The Available Laboratory Space Labeled Experiments Shall Be Performed In Cell Lysate Or Complex Bioliquids Experiments Using Cell Lysate Is Important To Be Able To Study Binding Interactions Under More Physiological Conditions 4 1 Delivery Installation Delivery Shall Be Within 90 Business Days Of Purchase Order Award All Shipping Handling Including Fob And Delivery Installation Fees Shall Be Included In The Quote Upon Delivery The Contractor Shall Notify The Nci Contracting Officer Representative Cor Tbd At Award To Schedule The Installation Date And Time That Shall Occur Within 14 Business Days After Delivery Installation Shall Be Performed By Or Under The Direct Supervision Of A Certified Operator The Contractor Shall Deliver And Install The Equipment At The Following Address Attn Tbd At Award Laboratory Of Cell Biology Center For Cancer Research National Cancer Institute National Institutes Of Health 37 Convent Drive Building 37 Rm 2140 Bethesda Md 20892 E Mail Tbd At Award Telephone Tbd At Award 4 2 Training Within 30 Business Days After Installation 1 Day Of Training Shall Be Provided On Site For At Least One Primary User For Each Instrument I E Two Days Of Training Total All Training Expenses Including Materials And Or Travel Expenses Shall Be Included In The Quoted Price 4 3Warranty A Minimum Of 12 Months Warranty From The Date Of Installation Shall Be Included Which Covers The Cost Of Repair And Or Replacement Including Labor Or Any Defect In Workmanship Or Parts 5 0 Payment Payment Shall Be Made Upon Delivery Inspection And Acceptance By The Government Payment Authorization Requires Submission And Approval Of Invoices To The Nci Cor And Nih Ofm In Accordance With The Payment Provisions Listed Below The Following Clause Is Applicable To All Purchase Orders Task Or Delivery Orders And Blanket Purchase Agreement Bpa Calls Prompt Payment Jan 2017 Far 52 232 25 Highlights Of This Clause And Nih Implementation Requirements Follow I Invoice Requirements A An Invoice Is The Contractor s Bill Or Written Request For Payment Under The Contract For Supplies Delivered Or Services Performed A Proper Invoice Is An Original Which Must Include The Items Listed In Subdivisions 1 Through 12 Below In Addition To The Requirements Of Far 32 9 If The Invoice Does Not Comply With These Requirements The Contractor Will Be Notified Of The Defect Within 7 Days After The Date The Designated Billing Office Received The Invoice 3 Days For Meat Meat Food Products Or Fish And 5 Days For Perishable Agricultural Commodities Dairy Products Edible Fats Or Oils With A Statement Of The Reasons Why It Is Not A Proper Invoice See Exceptions Under Ii Below Untimely Notification Will Be Taken Into Account In The Computation Of Any Interest Penalty Owed The Contractor Vendor Contractor Name Address Point Of Contact For The Invoice Name Title Telephone Number E Mail And Mailing Address Of Point Of Contact Remit To Address Name And Complete Mailing Address To Send Payment Remittance Name Must Match Exactly With Name On Original Order Contract If The Remittance Name Differs From The Legal Business Name Then Both Names Must Appear On The Invoice Invoice Date Unique Invoice S For All Invoices Per Vendor Regardless Of Site Nbs Document Number Formats Must Be Included For Awards Created In The Nbs Contract Number Purchase Order Number Task Or Delivery Order Number And Source Award Number E G Indefinite Delivery Contract Number General Services Administration Number Or Bpa Call Number And Bpa Parent Award Number Data Universal Numbering System Duns Or Duns 4 As Registered In The Central Contractor Registration Ccr Federal Taxpayer Identification Number Tin In Those Exceptional Cases Where A Contractor Does Not Have A Duns Number Or Tin A Vendor Identification Number Vin Must Be Referenced On The Invoice The Vin Is The Number That Appears After The Contractor S Name On The Face Page Of The Award Document Identify That Payment Is To Be Made Using A Three Way Match Of Supplies Services That Match The Description On The Award By Line Billed Freight Or Delivery Charge Must Be Billed As Shown On The Award If It Is Included In The Item Price Do Not Bill It Separately If Identified In The Award As A Separate Line Item It Must Be Billed Separately Quantity Unit Of Measure Unit Price Extended Price Of Supplies Delivered Or Services Performed As Applicable And That Match The Line Items Specified In The Award Note If Your Invoice Must Differ From The Line Items On The Award Please Contact The Contracting Officer Before Submitting The Invoice A Modification To The Order Or Contract May Be Needed Before The Invoice Can Be Submitted And Paid B Shipping Costs Will Be Reimbursed Only If Authorized By The Contract Purchase Order If Authorized Shipping Costs Must Be Itemized Where Shipping Costs Exceed 100 The Invoice Must Be Supported By A Bill Of Lading Or A Paid Carrier s Receipt C Mail An Original And 1 Copy Of The Itemized Invoice To National Institutes Of Health Office Of Financial Management Commercial Accounts 2115 East Jefferson Street Room 4B 432 Msc 8500 Bethesda Md 20892 8500 For Inquiries Regarding Payment Call 301 496 6088 In Order To Facilitate The Prompt Payment Of Invoices It Is Recommended That The Vendor Submit A Photocopy Of The Invoice To The Consignee Designated For The Acquisition In Blocks 6A 6E Of The Face Page Of The Order Award Document Ii Invoice Payment A Except As Indicated In Paragraph B Below The Due Date For Making Invoice Payments By The Designated Payment Office Shall Be The Later Of The Following Two Events 1 The 30Th Day After The Designated Billing Office Has Received A Proper Invoice 2 The 30Th Day After Government Acceptance Of Supplies Delivered Or Services Performed B The Due Date For Making Invoice Payments For Meat And Meat Food Products Perishable Agricultural Commodities Dairy Products And Edible Fats Or Oils Shall Be In Accordance With The Prompt Payment Act As Amended Iii Interest Penalties A An Interest Penalty Shall Be Paid Automatically If Payment Is Not Made By The Due Date And The Conditions Listed Below Are Met If Applicable 1 A Proper Invoice Was Received By The Designated Billing Office 2 A Receiving Report Or Other Government Documentation Authorizing Payment Was Processed And There Was No Disagreement Over Quantity Quality Or Contractor Compliance With A Term Or Condition 3 In The Case Of A Final Invoice For Any Balance Of Funds Due The Contractor For Supplies Delivered Or Services Performed The Amount Was Not Subject To Further Settlement Actions Between The Government And The Contractor B Determination Of Interest And Penalties Due Will Be Made In Accordance With The Provisions Of The Prompt Payment Act As Amended The Contract Disputes Act And Regulations Issued By The Office Of Management And Budget Iv Providing Accelerated Payment To Small Business Subcontractors Far 52 232 40 Dec 2013 A Upon Receiptof Accelerated Payments From The Government Thecontractor Shall Make Accelerated Payments To Its Small Business Subcontractors Under This Contract To The Maximum Extent Practicable And Prior To Whensuch Payment Is Otherwiserequired Under The Applicable Contract Or Subcontract After Receipt Of A Proper Invoice And All Other Required Documentation From The Small Business Subcontractor B Theacceleration Of Payments Under This Clause Does Not Provide Any New Rights Under The Prompt Payment Act Include The Substance Of This Clause Include This Paragraph C In All Subcontracts With Small Business Concerns Including Subcontracts With Small Businessconcerns For The Acquisition Of Commercial Items 6 0Clauses And Provisions Far 52 212 5 Contract Terms And Conditions Required To Implement Statutes Or Executive Orders Commercial Items Mar 2020 A The Contractor Shall Comply With The Following Federal Acquisition Regulation Far Clauses Which Are Incorporated In This Contract By Reference To Implement Provisions Of Law Or Executive Orders Applicable To Acquisitions Of Commercial Items 1 52 203 19 Prohibition On Requiring Certain Internal Confidentiality Agreements Or Statements Jan 2017 Section 743 Of Division E Title Vii Of The Consolidated And Further Continuing Appropriations Act 2015 Pub L 113 235 And Its Successor Provisions In Subsequentappropriations Acts And As Extended In Continuing Resolutions 2 52 204 23 Prohibition On Contracting For Hardware Software And Services Developed Or Provided By Kaspersky Lab And Other Covered Entities Jul2018 Section 1634 Of Pub L 115 91 3 52 204 25 Prohibition On Contracting For Certain Telecommunications And Video Surveillance Services Or Equipment Aug2019 Section 889 A 1 A Of Pub L 115 232 4 52 209 10 Prohibition On Contracting With Inverted Domestic Corporations Nov2015 5 52 233 3 Protest After Award Aug1996 31U S C 3553 6 52 233 4 Applicable Law For Breach Of Contract Claim Oct 2004 Public Laws 108 77 And 108 78 19U S C 3805Note B The Contractor Shall Comply With The Far Clauses In This Paragraph B That The Contracting Officer Has Indicated As Being Incorporated In This Contract By Reference To Implement Provisions Of Law Or Executive Orders Applicable To Acquisitions Of Commercial Items X 1 52 203 6 Restrictions On Subcontractor Sales To The Government Sept2006 With Alternate I Oct1995 41U S C 4704And10u S C 2402 2 52 203 13 Contractor Code Of Business Ethics And Conduct Oct2015 41U S C 3509 3 52 203 15 Whistleblower Protections Under The American Recovery And Reinvestment Act Of 2009 June2010 Section 1553 Of Pub L 111 5 Applies To Contracts Funded By The American Recovery And Reinvestment Act Of 2009 X 4 52 204 10 Reporting Executive Compensation And First Tier Subcontract Awards Oct2018 Pub L 109 282 31U S C 6101Note 5 Reserved 6 52 204 14 Service Contract Reporting Requirements Oct2016 Pub L 111 117 Section 743 Of Div C 7 52 204 15 Service Contract Reporting Requirements For Indefinite Delivery Contracts Oct2016 Pub L 111 117 Section 743 Of Div C X 8 52 209 6 Protecting The Government S Interest When Subcontracting With Contractors Debarred Suspended Or Proposed For Debarment Oct2015 31U S C 6101Note 9 52 209 9 Updates Of Publicly Available Information Regarding Responsibility Matters Oct2018 41U S C 2313 10 Reserved 11 I 52 219 3 Notice Of Hubzone Set Aside Or Sole Source Award Mar 2020 15U S C 657A Ii Alternate I Mar 2020 Of52 219 3 12 I 52 219 4 Notice Of Price Evaluation Preference For Hubzone Small Business Concerns Mar 2020 If The Offeror Elects To Waive The Preference It Shall So Indicate In Its Offer 15U S C 657A Ii Alternate I Mar 2020 Of52 219 4 13 Reserved X 14 I 52 219 6 Notice Of Total Small Business Set Aside Mar 2020 15U S C 644 Ii Alternate I Mar 2020 Iii Alternate Ii Nov2011 15 I 52 219 7 Notice Of Partial Small Business Set Aside Mar 2020 15U S C 644 Ii Alternate I Mar 2020 Of52 219 7 Iii Alternate Ii Mar2004 Of52 219 7 X 16 52 219 8 Utilization Of Small Business Concerns Oct2018 15U S C 637 D 2 And 3 17 I 52 219 9 Small Business Subcontracting Plan Mar2020 15U S C 637 D 4 Ii Alternate I Nov2016 Of52 219 9 Iii Alternate Ii Nov2016 Of52 219 9 Iv Alternate Iii Mar 2020 Of52 219 9 V Alternate Iv Aug 2018 Of52 219 9 X 18 52 219 13 Notice Of Set Aside Of Orders Mar 2020 15U S C 644 R X 19 52 219 14 Limitations On Subcontracting Mar 2020 15U S C 637 A 14 20 52 219 16 Liquidated Damages Subcontracting Plan Jan1999 15U S C 637 D 4 F I 21 52 219 27 Notice Of Service Disabled Veteran Owned Small Business Set Aside Mar 2020 15U S C 657F X 22 I 52 219 28 Post Award Small Business Program Rerepresentation Mar 2020 15U S C 632 A 2 Ii Alternate I Mar 2020 Of52 219 28 23 52 219 29 Notice Of Set Aside For Or Sole Source Award To Economically Disadvantaged Women Owned Small Business Concerns Mar 2020 15U S C 637 M 24 52 219 30 Notice Of Set Aside For Or Sole Source Award To Women Owned Small Business Concerns Eligible Under The Women Owned Small Business Program Mar2020 15U S C 637 M X 25 52 219 32 Orders Issued Directly Under Small Business Reserves Mar 2020 15 U S C 644 R X 26 52 219 33 Nonmanufacturer Rule Mar 2020 15 U S C 637 A 17 X 27 52 222 3 Convict Labor June2003 E O 11755 X 28 52 222 19 Child Labor Cooperation With Authorities And Remedies Jan2020 E O 13126 X 29 52 222 21 Prohibition Of Segregated Facilities Apr2015 X 30 I 52 222 26 Equal Opportunity Sept2016 E O 11246 Ii Alternate I Feb1999 Of52 222 26 X 31 I 52 222 35 Equal Opportunity For Veterans Oct2015 38U S C 4212 Ii Alternate I July2014 Of52 222 35 X 32 I 52 222 36 Equal Opportunity For Workers With Disabilities Jul2014 29U S C 793 Ii Alternate I July 2014 Of52 222 36 X 33 52 222 37 Employment Reports On Veterans Feb 2016 38U S C 4212 34 52 222 40 Notification Of Employee Rights Under The National Labor Relations Act Dec2010 E O 13496 35 I 52 222 50 Combating Trafficking In Persons Jan2019 22U S C Chapter78and E O 13627 Ii Alternate I Mar2015 Of52 222 50 22U S C Chapter78and E O 13627 36 52 222 54 Employment Eligibility Verification Oct 2015 Executive Order 12989 Not Applicable To The Acquisition Of Commercially Available Off The Shelf Items Or Certain Other Types Of Commercial Items As Prescribed In22 1803 37 I 52 223 9 Estimate Of Percentage Of Recovered Material Content For Epa Designated Items May2008 42U S C 6962 C 3 A Ii Not Applicable To The Acquisition Of Commercially Available Off The Shelf Items Ii Alternate I May2008 Of52 223 9 42U S C 6962 I 2 C Not Applicable To The Acquisition Of Commercially Available Off The Shelf Items 38 52 223 11 Ozone Depleting Substances And High Global Warming Potential Hydrofluorocarbons Jun2016 E O 13693 39 52 223 12 Maintenance Service Repair Or Disposal Of Refrigeration Equipment And Air Conditioners Jun2016 E O 13693 40 I 52 223 13 Acquisition Of Epeat Registered Imaging Equipment Jun 2014 E O S 13423 And 13514 Ii Alternate I Oct2015 Of52 223 13 41 I 52 223 14 Acquisition Of Epeat Registered Televisions Jun2014 E O S 13423 And 13514 Ii Alternate I Jun2014 Of52 223 14 X 42 52 223 15 Energy Efficiency In Energy Consuming Products Dec 2007 42U S C 8259B 43 I 52 223 16 Acquisition Of Epeat Registered Personal Computer Products Oct 2015 E O S 13423 And 13514 Ii Alternate I Jun2014 Of52 223 16 44 52 223 18 Encouraging Contractor Policies To Ban Text Messaging While Driving Aug 2011 E O 13513 45 52 223 20 Aerosols Jun2016 E O 13693 46 52 223 21 Foams Jun2016 E O 13693 47 I 52 224 3Privacy Training Jan2017 5 U S C 552 A Ii Alternate I Jan2017 Of52 224 3 48 52 225 1 Buy American Supplies May2014 41U S C Chapter83 X 49 I 52 225 3 Buy American Free Trade Agreements Israeli Trade Act May2014 41U S C Chapter83 19U S C 3301Note 19U S C 2112Note 19U S C 3805Note 19U S C 4001Note Pub L 103 182 108 77 108 78 108 286 108 302 109 53 109 169 109 283 110 138 112 41 112 42 And 112 43 Ii Alternate I May2014 Of52 225 3 Iii Alternate Ii May2014 Of52 225 3 Iv Alternate Iii May2014 Of52 225 3 50 52 225 5 Trade Agreements Oct 2019 19U S C 2501 Et Seq 19U S C 3301Note 51 52 225 13 Restrictions On Certain Foreign Purchases June2008 E O S Proclamations And Statutes Administered By The Office Of Foreign Assets Control Of The Department Of The Treasury 52 52 225 26 Contractors Performing Private Security Functions Outside The United States Oct2016 Section 862 As Amended Of The National Defense Authorization Act For Fiscal Year 2008 10U S C 2302Note 53 52 226 4 Notice Of Disaster Or Emergency Area Set Aside Nov2007 42U S C 5150 54 52 226 5 Restrictions On Subcontracting Outside Disaster Or Emergency Area Nov2007 42U S C 5150 X 55 52 232 29 Terms For Financing Of Purchases Of Commercial Items Feb2002 41U S C 4505 10U S C 2307 F 56 52 232 30 Installment Payments For Commercial Items Jan2017 41U S C 4505 10U S C 2307 F 57 52 232 33 Payment By Electronic Funds Transfer System For Award Management Oct2018 31U S C 3332 58 52 232 34 Payment By Electronic Funds Transfer Other Than System For Award Management Jul2013 31 U S C 3332 59 52 232 36 Payment By Third Party May2014 31U S C 3332 60 52 239 1 Privacy Or Security Safeguards Aug1996 5U S C 552A 61 52 242 5 Payments To Small Business Subcontractors Jan2017 15U S C 637 D 13 62 I 52 247 64 Preference For Privately Owned U S Flag Commercial Vessels Feb2006 46U S C Appx 1241 B And10u S C 2631 Ii Alternate I Apr2003 Of52 247 64 Iii Alternate Ii Feb2006 Of52 247 64 C The Contractor Shall Comply With The Far Clauses In This Paragraph C Applicable To Commercial Services That The Contracting Officer Has Indicated As Being Incorporated In This Contract By Reference To Implement Provisions Of Law Or Executive Orders Applicable To Acquisitions Of Commercial Items 1 52 222 17 Nondisplacement Of Qualified Workers May2014 E O 13495 2 52 222 41 Service Contract Labor Standards Aug2018 41U S C Chapter67 3 52 222 42 Statement Of Equivalent Rates For Federal Hires May2014 29U S C 206And41u S C Chapter 67 4 52 222 43 Fair Labor Standards Act And Service Contract Labor Standards Price Adjustment Multiple Year And Option Contracts Aug2018 29U S C 206And41u S C Chapter67 5 52 222 44 Fair Labor Standards Act And Service Contract Labor Standards Price Adjustment May2014 29U S C 206And41u S C Chapter67 6 52 222 51 Exemption From Application Of The Service Contract Labor Standards To Contracts For Maintenance Calibration Or Repair Of Certain Equipment Requirements May2014 41U S C Chapter67 X 7 52 222 53 Exemption From Application Of The Service Contract Labor Standards To Contracts For Certain Services Requirements May2014 41U S C Chapter67 8 52 222 55 Minimum Wages Under Executive Order 13658 Dec2015 9 52 222 62 Paid Sick Leave Under Executive Order 13706 Jan2017 E O 13706 10 52 226 6 Promoting Excess Food Donation To Nonprofit Organizations May2014 42U S C 1792 D Comptroller General Examination Of Record The Contractor Shall Comply With The Provisions Of This Paragraph D If This Contract Was Awarded Using Other Than Sealed Bid Is In Excess Of The Simplified Acquisition Threshold And Does Not Contain The Clause At52 215 2 Audit And Records Negotiation 1 The Comptroller General Of The United States Or An Authorized Representative Of The Comptroller General Shall Have Access To And Right To Examine Any Of The Contractor S Directly Pertinent Records Involving Transactions Related To This Contract 2 The Contractor Shall Make Available At Its Offices At All Reasonable Times The Records Materials And Other Evidence For Examination Audit Or Reproduction Until 3 Years After Final Payment Under This Contract Or For Any Shorter Period Specified In Farsubpart 4 7 Contractor Records Retention Of The Other Clauses Of This Contract If This Contract Is Completely Or Partially Terminated The Records Relating To The Work Terminated Shall Be Made Available For 3 Years After Any Resulting Final Termination Settlement Records Relating To Appeals Under The Disputes Clause Or To Litigation Or The Settlement Of Claims Arising Under Or Relating To This Contract Shall Be Made Available Until Such Appeals Litigation Or Claims Are Finally Resolved 3 As Used In This Clause Records Include Books Documents Accounting Procedures And Practices And Other Data Regardless Of Type And Regardless Of Form This Does Not Require The Contractor To Create Or Maintain Any Record That The Contractor Does Not Maintain In The Ordinary Course Of Business Or Pursuant To A Provision Of Law E 1 Notwithstanding The Requirements Of The Clauses In Paragraphs A B C And D Of This Clause The Contractor Is Not Required To Flow Down Any Far Clause Other Than Those In This Paragraph E 1 In A Subcontract For Commercial Items Unless Otherwise Indicated Below The Extent Of The Flow Down Shall Be As Required By The Clause I 52 203 13 Contractor Code Of Business Ethics And Conduct Oct2015 41U S C 3509 Ii 52 203 19 Prohibition On Requiring Certain Internal Confidentiality Agreements Or Statements Jan 2017 Section 743 Of Division E Title Vii Of The Consolidated And Further Continuing Appropriations Act 2015 Pub L 113 235 And Its Successor Provisions In Subsequent Appropriations Acts And As Extended In Continuing Resolutions Iii 52 204 23 Prohibition On Contracting For Hardware Software And Services Developed Or Provided By Kaspersky Lab And Other Covered Entities Jul 2018 Section 1634 Of Pub L 115 91 Iv 52 204 25 Prohibition On Contracting For Certain Telecommunications And Video Surveillance Services Or Equipment Aug 2019 Section 889 A 1 A Of Pub L 115 232 V 52 219 8 Utilizationof Small Business Concerns Oct2018 15U S C 637 D 2 And 3 In All Subcontracts That Offer Further Subcontracting Opportunities If The Subcontract Except Subcontracts To Small Business Concerns Exceeds 700 000 1 5 Million For Construction Of Any Public Facility The Subcontractor Must Include52 219 8In Lower Tier Subcontracts That Offer Subcontracting Opportunities Vi 52 222 17 Nondisplacementof Qualified Workers May2014 E O 13495 Flow Down Required In Accordance With Paragraph L Of Far Clause52 222 17 Vii 52 222 21 Prohibitionof Segregated Facilities Apr2015 Viii 52 222 26 Equalopportunity Sept2015 E O 11246 Ix 52 222 35 Equalopportunity For Veterans Oct2015 38U S C 4212 X 52 222 36 Equalopportunity For Workers With Disabilities Jul2014 29U S C 793 Xi 52 222 37 Employmentreports On Veterans Feb2016 38U S C 4212 Xii 52 222 40 Notificationof Employee Rights Under The National Labor Relations Act Dec2010 E O 13496 Flow Down Required In Accordance With Paragraph F Of Far Clause52 222 40 Xiii 52 222 41 Servicecontract Labor Standards Aug2018 41U S C Chapter67 Xiv A 52 222 50 Combatingtrafficking In Persons Jan2019 22U S C Chapter78and E O 13627 B Alternate I Mar2015 Of52 222 50 22U S C Chapter78and E O 13627 Xv 52 222 51 Exemptionfrom Application Of The Service Contract Labor Standards To Contracts For Maintenance Calibration Or Repair Of Certain Equipment Requirements May2014 41U S C Chapter67 Xvi 52 222 53 Exemptionfrom Application Of The Service Contract Labor Standards To Contracts For Certain Services Requirements May2014 41U S C Chapter67 Xvii 52 222 54 Employmenteligibility Verification Oct 2015 E O 12989 Xviii 52 222 55 Minimumwages Under Executive Order 13658 Dec2015 Xix 52 222 62 Paidsick Leave Under Executive Order 13706 Jan2017 E O 13706 Xx A 52 224 3 Privacytraining Jan2017 5U S C 552A B Alternate I Jan2017 Of52 224 3 Xxi 52 225 26 Contractorsperforming Private Security Functions Outside The United States Oct2016 Section 862 As Amended Of The National Defense Authorization Act For Fiscal Year 2008 10U S C 2302 Note Xxii 52 226 6 Promotingexcess Food Donation To Nonprofit Organizations May2014 42U S C 1792 Flow Down Required In Accordance With Paragraph E Of Far Clause52 226 6 Xxiii 52 247 64 Preferencefor Privately Owned U S Flag Commercial Vessels Feb2006 46U S C Appx 1241 B And10u S C 2631 Flow Down Required In Accordance With Paragraph D Of Far Clause52 247 64 2 While Not Required The Contractor May Include In Its Subcontracts For Commercial Items A Minimal Number Of Additional Clauses Necessary To Satisfy Its Contractual Obligations Far 52 252 2 Clauses Incorporated By Reference Feb 1998 This Contract Incorporates One Or More Clauses By Reference With The Same Force And Effect As If They Were Given In Full Text Upon Request The Contracting Officer Will Make Their Full Text Available Also The Full Text Of A Clause May Be Accessed Electronically At This These Address Es Http Www Acquisition Gov Far And Or Http Www Hhs Gov Policies Hhsar Federal Acquisition Regulation Far 48 Cfr Chapter 1 Provisions Clause No Title Far 52 203 17Contractor Employee Whistleblower Rights And Requirement To Inform Employees Of Whistleblower Rights Apr 2014 Far 52 203 18 Prohibition On Contracting With Entities That Require Certain Internal Confidentiality Agreements Or Statements Representation Jan 2017 Far 52 203 19Prohibition On Requiring Certain Internal Confidentiality Agreements Or Statements Jan 2017 Far 52 204 25 Prohibition On Contracting For Certain Telecommunications And Video Surveillance Services Or Equipment Aug 2019 Far 52 212 4 Contract Terms And Conditions Commercial Items Oct 2018 Far 52 232 39Unenforceability Of Unauthorized Obligations Jun 2013 Far 52 247 35 F O B Destination Within Consignee S Premises Apr 1984 Health And Human Serices Acquisition Regulation Hhsar 48 Cfr Chapter 3 Provisions Clause No Title Hhsar 352 203 70 Anti Lobbying Dec 2015 Hhsar 352 208 70 Printing And Duplication Dec 2015 Hhsar 352 222 70Contractor Cooperation In Equal Employment Opportunity Investigation Dec2015 Hhsar 352 224 71Confidential Information Dec 2015 Hhsar 352 227 70Publications And Publicity Dec 2015 Hhsar 352 237 74Non Discrimination In Service Delivery Dec 2015 Solicitation Provisions Far 52 204 24 Representation Regarding Certain Telecommunications And Video Surveillance Services Or Equipment Dec 2019 A Definitions As Used In This Provision Covered Telecommunications Equipment Or Services Critical Technology And Substantial Or Essential Component Have The Meanings Provided In Clause 52 204 25 Prohibition On Contracting For Certain Telecommunications And Video Surveillance Services Or Equipment B Prohibition Section 889 A 1 A Of The John S Mccain National Defense Authorization Act For Fiscal Year 2019 Pub L 115 232 Prohibits The Head Of An Executive Agency On Or After August 13 2019 From Procuring Or Obtaining Or Extending Or Renewing A Contract To Procure Or Obtain Any Equipment System Or Service That Uses Covered Telecommunications Equipment Or Services As A Substantial Or Essential Component Of Any System Or As Critical Technology As Part Of Any System Contractors Are Not Prohibited From Providing A Service That Connects To The Facilities Of A Third Party Such As Backhaul Roaming Or Interconnection Arrangements Or Telecommunications Equipment That Cannot Route Or Redirect User Data Traffic Or Permit Visibility Into Any User Data Or Packets That Such Equipment Transmits Or Otherwise Handles C Procedures The Offeror Shall Review The List Of Excluded Parties In The System For Award Management Sam Https Www Sam Gov For Entities Excluded From Receiving Federal Awards For Covered Telecommunications Equipment Or Services D Representation The Offeror Represents That It Will Will Not Provide Covered Telecommunications Equipment Or Services To The Government In The Performance Of Any Contract Subcontract Or Other Contractual Instrument Resulting From This Solicitation E Disclosures If The Offeror Has Represented In Paragraph D Of This Provision That It Will Provide Covered Telecommunications Equipment Or Services The Offeror Shall Provide The Following Information As Part Of The Offer A Description Of All Covered Telecommunications Equipment And Services Offered Include Brand Model Number Such As Original Equipment Manufacturer Oem Number Manufacturer Part Number Or Wholesaler Number And Item Description As Applicable Explanation Of The Proposed Use Of Covered Telecommunications Equipment And Services And Any Factors Relevant To Determining If Such Use Would Be Permissible Under The Prohibition In Paragraph B Of This Provision For Services The Entity Providing The Covered Telecommunications Services Include Entity Name Unique Entity Identifier And Commercial And Government Entity Cage Code If Known And For Equipment The Entity That Produced The Covered Telecommunications Equipment Include Entity Name Unique Entity Identifier Cage Code And Whether The Entity Was The Oem Or A Distributor If Known Far 52 211 6 Brand Name Or Equal Aug 1999 A If An Item In This Solicitation Is Identified As Brand Name Or Equal The Purchase Description Reflects The Characteristics And Level Of Quality That Will Satisfy The Government S Needs The Salient Physical Functional Or Performance Characteristics That Equal Products Must Meet Are Specified In The Solicitation B To Be Considered For Award Offers Of Equal Products Including Equal Products Of The Brand Name Manufacturer Must 1 Meet The Salient Physical Functional Or Performance Characteristic Specified In This Solicitation 2 Clearly Identify The Item By I Brand Name If Any And Ii Make Or Model Number 3 Include Descriptive Literature Such As Illustrations Drawings Or A Clear Reference To Previously Furnished Descriptive Data Or Information Available To The Contracting Officer And 4 Clearly Describe Any Modifications The Offeror Plans To Make In A Product To Make It Conform To The Solicitation Requirements Mark Any Descriptive Material To Clearly Show The Modifications C The Contracting Officer Will Evaluate Equal Products On The Basis Of Information Furnished By The Offeror Or Identified In The Offer And Reasonably Available To The Contracting Officer The Contracting Officer Is Not Responsible For Locating Or Obtaining Any Information Not Identified In The Offer D Unless The Offeror Clearly Indicates In Its Offer That The Product Being Offered Is An Equal Product The Offeror Shall Provide The Brand Name Product Referenced In The Solicitation Far 52 252 1 Solicitation Provisions Incorporated By Reference Feb 1998 This Solicitation Incorporates One Or More Solicitation Provisions By Reference With The Same Force And Effect As If They Were Given In Full Text Upon Request The Contracting Officer Will Make Their Full Text Available The Offeror Is Cautioned That The Listed Provisions May Include Blocks That Must Be Completed By The Offeror And Submitted With Its Quotation Or Offer In Lieu Of Submitting The Full Text Of Those Provisions The Offeror May Identify The Provision By Paragraph Identifier And Provide The Appropriate Information With Its Quotation Or Offer Also The Full Text Of A Solicitation Provision May Be Accessed Electronically At This These Address Es Http Www Acquisition Gov Far And Or Http Www Hhs Gov Policies Hhsar Federal Acquisition Regulation Far 48 Cfr Chapter 1 Provisions Clause No Title Far 52 204 22 Alternative Line Item Proposal Jan 2017 Far 52 212 1 Instructions To Offerors Commercial Items Oct 2018 Far 52 212 2 Evaluation Commercial Items Oct 2014 Far 52 214 21 Descriptive Literature Apr 2002 Submission Instructions Evaluation Questions Questions Must Be Submitted Electronically Via Email To Contract Specialist Adam Hernandez At Adam Hernandez Nih Gov In Ms Word Or Adobe Portable Document Format Pdf No Later Than 11 00 A M Est Monday April 06 2020 04 06 2020 Please Be Advised That The Government Reserves The Right To Transmit Any Questions And Answers Of A Common Interest To All Prospective Contractors Quotations Quotations Must Be Submitted Electronically Via Email To Contract Specialist Adam Hernandez At Adam Hernandez Nih Gov In Ms Word Or Adobe Portable Document Format Pdf No Later Than No Later Than 11 00 A M Est Friday April 10 2020 04 10 2020 Please Refer To Solicitation No 75N91020q00025 On All Correspondence Basis For Award Amp Evaluation The Purchase Order Will Be Awarded To The Firm That Submits The Lowest Price Technically Acceptable Lpta Quotation A Technically Acceptable Quote Is One In Which The Quoter S Complies With The Statement Of Need Son And Does Not Take Exception Nor Object To Any Of The Terms Of The Rfq Quotes That Are Not Technically Acceptable Will Not Be Considered For Award Award Will Be Made On An All Or None Basis If You Are Providing An Equal Product You Must Submit Additional Documentation That Highlights And Describes How Your Offering Is Equal In Accordance With Far Clause 52 211 6 Evaluation And Award Will Be Conducted In Accordance With The Requirements Of Far 13 106 The Technical Evaluation Will Be A Determination Based On Information Furnished By The Contractor The Government Is Not Responsible For Locating Or Securing Any Information Which Is Not Identified In The Quotation The Government Intends To Evaluate Quotations And Make A Single Award Quotations Should Contain The Quoter S Best Terms From A Price And Technical Standpoint However The Government Reserves The Right To Request Quote Revisions That Seek Additional Price Discounts Provide Revisions To The Technical Quote Or Clarify Aspects Of The Quote In The Event Quote Revisions Are Requested The Government Will Not Necessarily Be Seeking Revisions From All Quoters The Government May Reject Any Or All Quotes If Such Action Is In The Public Interest Accept Other Than The Lowest Quote And Waive Informalities And Minor Irregularities In Quotes Received General Instructions This Request For Quotation Rfq Does Not Commit The Government To Pay Any Cost For Preparation And Submission Of A Quote In Addition The Contracting Officer Is The Only Individual Who Can Legally Commit The Government To The Expenditure Of Public Funds In Connection With This Proposed Acquisition By Submitting A Quote In Response To This Solicitation It Is Understood That Your Firm S Quote Shall Become A Part Of The Official Contract File Quotes Must Be Submitted With A Completed Copy Of Far 52 204 24 Representation Regarding Certain Telecommunications And Video Surveillance Services Or Equipment Located In The Solicitation Provisions Section Of This Rfq Price Quote The Quoter Shall Prepare A Price Quotation That Contains All Information Necessary To Allow For A Comprehensive Evaluation Of The Prices Quoted The Quote Must Contain The Following Information A Federal Tax Identification Number Tin B Data Universal Numbering System Duns Number C Business Size E G Small Or Large Please Include A Statement To The Effect That Pricing Is Firm For A Period Of At Least 60 Days From The Date Of Receipt Thereof By The Government

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